Hello, my partner! Let's explore the mining machine together!

[email protected]

system sand production line workflow

a complete green sand solution: disa and wheelabrator fit out dianzhans brand new jiujiang foundry | foundry-planet.com - b2b portal

a complete green sand solution: disa and wheelabrator fit out dianzhans brand new jiujiang foundry | foundry-planet.com - b2b portal

State-of-the-art technologies from Noricans DISA and Wheelabrator brands have come together in a complete green sand solution for Dianzhan (Jiujiang) Metal Materials Co., Ltd. Constructed in only six months, the new Norican production line exactly fits Dianzhans requirement for a compact, fully automated and energy-efficient facility that will triple the companys annual iron output.

Challenges:Compact layout for efficient casting Established in September 2005 and starting production in May 2006, Dianzhan produces around 12,000 tons annually at its original foundry site. In 2018, the company decided to more than triple its overall capacity by building a completely new, additional Jiujiang facility in Jiangxi province, China, with a projected annual casting output of 26,000 tons. Construction began in August 2018, with the first production castings appearing only six months later in February 2019.

Occupying minimum factory floor space, while delivering rapid, flexible and low-cost production, the new foundry specialises in the casting and processing of compressor parts and automotive parts, such as cylinders, bearings and other components. The technology delivered by Norican is already hitting its targets for productivity and scrap elimination.

Solution:Efficient, lean production with seamless automation DISA and Wheelabrator worked together to select exactly the right equipment to match Dianzhans specifications, with every workflow planned for maximum, automated efficiency. The entire production line runs automatically and continuously, from sand preparation and iron melting through to moulding, pouring, shake-out and blasting. Every work area and piece of equipment is seamlessly and automatically coordinated with its neighbouring process and the moulding line.

This neatly-packaged, integrated complete green sand solution for the foundry has a compact layout, minimising the distance between all the different foundry process stages. This translates into reduced manpower requirements, shorter distances for materials to move and no need for forklifts in the plant area. The space saved also leaves room for other equipment to be installed in future. The sand plant employs DISAs classic double cooling drum design combined with a high-efficiency control module. With consistent sand quality and the minimal distance between sand production and the moulding line, moulding sand can be prepared and used only when needed by the moulding line.

Perfectly matched plant and dust-free too The DISAMATIC D3 vertical moulding machine lies at the heart of the moulding line and combines high speed with exceptional yield and quality. Throughput is blisteringly fast: up to 485 moulds per hour with core setting and 555 moulds per hour without, all with a mould misalignment of less than 0.01 mm. After cooling and shake-out, Wheelabrators DT14-450 rocker-barrel-type shot blasting machine cleans the castings by gently tumbling parts in through-feed operation. Fully automated like the rest of the production equipment and working continuously, its small footprint helps it fit easily onto the tightly-packed factory floor. DT shot blast machines require no loading or unloading and cope easily with changing parts, types or volumes.

Shot blasting operations are dust-free, like all the new foundrys work areas. Part of the integrated complete green sand solution, the design embraces every piece of plant to effectively improve overall dust removal performance and helps Dianzhan meet the increasingly stringent environmental requirements facing iron foundries. Condensation is a major challenge in dust removal: if not handled in time, it can easily paralyse the production line. The integrated plant design tackles condensation at every stage of the casting process. For example, DISAs new heating furnace employs heating and insulation treatment within the parts of the sand treatment system with high levels of moisture.

Result:Smooth transition to full production Implemented rapidly and working to specification, the complete green sand solution is reliable, easy to maintain and delivers consistent quality. As the foundry plant ramped up production in the first half of 2019, the scrap rate remained below 1% and the integrated plants monthly output quickly reached 1,000 tons. The new Jiujiang plant is now well on the way to helping Dianzhan triple its annual production volume.

Mr. Chien Chuan Lin, Production Manager at Dianzhan, comments: When we started to plan this project with DISA, we had four main targets. We wanted to improve the utilization of the workshop, minimize the logistical distances involved and build a fully-automated line that was also very energy-efficient. After running at full operating status for the last few months, we can confirm that all four of these targets have been achieved at our Jiujiang plant.

workflows | new vaccine technology | mammalian cell lines | solentim

workflows | new vaccine technology | mammalian cell lines | solentim

Traditional vaccine technology has used eggs to manufacture vaccines for common diseases including influenza, a process which is inexpensive and well established. As the viruses replicate in the egg factories, mutations can arise, impacting the effectiveness of the vaccine. Compared with the these egg-based manufacturing techniques, mammalian cell-based production process offers greater stability of DNA sequences and enhanced quality control.

Using a mammalian cell-based system, there is no limitation on the availability of eggs and avoids supply chain risk. Producer cells used to manufacture vaccines are stored frozen, banked, to assure a readily scalable supply of cells for vaccine production. This enhanced turn around speed can be crucial during a pandemic, where time means lives saved. In addition, when the production schedule is tight, it can also provide a first-market advantage for the vaccine manufacturers.

The advantage of mammalian cell lines for the production of recombinant sub-unit vaccines is their ability to produce secreted proteins as protective antigens in serum-free media at high levels and robustly, and the ability to introduce correct protein folding, post-translational modifications and product assembly into the produced proteins. The complete biological activity of the protein makes it an effective vaccine candidate.

There was a highly relevant paper published in the journal Vaccine by Nyon et al (2018) on sub-unit vaccine production in engineered stable CHO cell line for MERS-Coronavirus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860679/

Monoclonals are targeted directly against antigens on the infectious diseases. Candidate antibodies can be identified using the classical antigen display techniques or more recently taken the B-cell IgG repertoire from surviving patients serum and deep sequencing. The list of effective vaccines against Ebola includes the identification of mAb114 antibody from a surviving patient and REGN-EB3, a combination of three monoclonal antibodies. Central to the supply of antibody-based vaccines is the manufacture within robust mammalian host cell lines.

CHO and myeloma cells e.g. NS0, and Vero cells are some of the most commonly used host cells for the construction of stable cell lines. The vaccines produced by the cells are secreted extracellularly so that the product can be harvested from the cell culture medium.

Stable cell lines are required for industrial production of recombinant protein vaccines. These must have the ability to produce the same high quality products at different times, at different geographical sites and between different batches. After selecting the cell line for production, it is necessary to establish a Master Cell Bank (MCB).

Protection of the manufacturing capacity of immortalised cell lines expressing a vaccine product is critical to protect the supply of a marketed drug. Heterogeneity in the population can lead to instability as discussed by the FDA concerning the production of biologics (reference Welch JT & Arden NS, Biologicals, Sep 2019) . Ensuring that the cell line was derived from a single cell, 'clonally-derived', can lead to a more robust cell line.Current best practice with immortalised cell lines producing a vaccine is to perform single-cell isolation with systems, such as the VIPS and to monitor clonal outgrowth with the Cell Metric. The history of the clone is then documented by way of the Clonality Report which can be submitted to the regulator.

The workflow steps for stable cell lines for vaccine production are very similar to those outlined for the cell line development for biotherapeutics. Speed of cell line development is especially important in this case in order to quickly combat a potential pandemic: using the Solentim approach, the time from transfection to cell banking can be achieved in as little as 12 weeks.

It should be noted that there are some key workflow differences in modern vaccine technology in comparison to conventional IgG production. Firstly, generating a sub-unit protein will necessitate developing novel immunoassays that can quantitate the recombinant protein and determine efficacy. Secondly, for the production of monoclonal antibody vaccines, while these can be assessed using well-developed assays for antibody titer determination, custom functional assays will also need to be developed to determine the affinity of the antibodies against the infectious agent.

Li, X, Zhang, Y, Jing, L, et al. Integration of highthroughput analytics and cell imaging enables direct early productivity and product quality assessment during Chinese Hamster ovary cell line development for a complex multisubunit vaccine antigen. Biotechnol Progress., published 30 September 2019. https://doi.org/10.1002/btpr.2914

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.

production & manufacturing process flow charts & workflow templates | opsdog

production & manufacturing process flow charts & workflow templates | opsdog

Manufacturing process workflows, or flow charts, detail the granular activity-level steps that must be completed to create finished goods from the time raw materials are received at the manufacturing facility until those materials are turned into finished goods. Companies in all manufacturing industries are constantly looking for ways to achieve continuous process improvement (e.g., Lean Six Sigma, Total Quality Management, Just-in-Time Production, etc.), and flow charts are one of many tools that can help organizations optimize their manufacturing processes.

Manufacturing processes typically follow a strict set of rules or guidelines in order to turn raw materials into a quality finished product. Any deviation from standard manufacturing processes can lead to machine malfunction, elongated lead times or excessive scrap rates. In-depth and detailed analysis of manufacturing processes can be reinforced through the use of flow charts a few examples:

Standardize Production Run Setup Activities: Inefficient manufacturing setup procedures can be very costly (financial and otherwise) to an organization. A well-documented and detailed flow chart describing the exact steps required to prepare a new production run is pivotal for reducing lead times and increasing machine utilization.

Create Flow Charts for Preventative Maintenance Procedures and Notification: Develop standard preventative maintenance (PM) processes for each machine in the manufacturing process. Following these processes and developing protocols for notifying machine operators of PM schedules will allow employees to plan ahead and do other work while machines are being inspected.

Identify Root Causes of Defects Using Flow Charts: Flow charts can enable manufacturers to analyze their manufacturing process step-by-step in detail, which can help in diagnosing which activities are leading to higher defect and scrap rates.

Manufacturing processes may vary across manufacturing industries. For example, food processing and manufacturing will require different activities from automobile or heavy equipment manufacturing. However, most manufacturing industries follow the same manufacturing processes outlined below:

Production Planning: Works closely with procurement and material management functions to ensure raw materials and other prerequisites are prepared for production runs. Flow charts should be utilized to dictate efficient communication protocols among functional teams.

Manufacturing Engineering: This phase consists of designing the systems and processes required to complete high-quality production runs. Flow charts and workflows are necessary to aid in the design of assembly processes.

Manufacturing & Assembly: The manufacturing & assembly stage includes setting up the facility for production runs and putting the materials through to completion. Creating flow charts of the production run allow you to measure KPIs (e.g., Defects Prior to Assembly, Product Mixing Time, etc.) for specific yet critical steps in the assembly process.

Quality Assurance: The quality assurance function is responsible for inspecting finished goods after going through the manufacturing process. Checklists and flow charts need to be created to standardize finished goods inspection and ensure any defect can be detected and mitigated in the future.

Facility Management: Maintaining the equipment, safety and overall environment of the manufacturing facilities requires specific protocols for PM, temperature, space usage, etc. Flow charts ensure consistency among facility management tasks and promote transparency as employees need to know facility maintenance schedules and processes.

Related News
  1. milling production line automation
  2. ball mill seller california
  3. rod mill process of manufacturing rod mill process of
  4. equipment used in iron ore production
  5. sale of ball grinding mill
  6. ball mill this subject
  7. cost of grinding in gold production stone crusher for sale
  8. new quartz mineral processing production line in tokyo
  9. ball bearing
  10. monrovia high quality small kaolin ceramic ball mill manufacturer
  11. africa low price large limestone trommel screen
  12. crypto currency mining equipments
  13. high capacity bucket elevators
  14. high end large mineral high frequency screen sell in tunisia
  15. price list jaw crusher feed size mm
  16. brasov environmental bauxite rock crusher for sale
  17. ball milling facility in cipet hyderabad
  18. high quality ball mill 1 5*5 7 m almost new
  19. cement vs concrete
  20. cone crusher video download